Hypotensive Effects of Single Intravenous and Single Oral Doses of Mecamylamine Intravenous

Stone and his co-workers * have reported recently on certain unusual pharmacological properties of mecamylamine (3-methylaminoisocamphane) hydrochloride. This compound, a secondary amine, produces a marked and prolonged degree of blood pressure reduction and ganglionic blockade in animals. Blecamylamine also is well absorbed from the gastrointestinal tract, the L. D.so being approximately the same whether the drug is adminished subcutaneously or orally. By contrast, previously successful ganglion-blocking agents, which are tertiary amines, are poorly absorbed from the gastrointestinal tract. The ratio of oral